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925462

Sigma-Aldrich

Maleimide poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA average Mn 15,000, lactide:glycolide 50:50

Synonym(s):

Maleimide-PEG-b-PLGA, Maleimide-PEG-PLGA

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About This Item

Linear Formula:
C13H19SN2O4(C2H4O)nC2H4O[(C2H2O2)x(C3H4O2)y]m
UNSPSC Code:
12352111
NACRES:
NA.23

feed ratio

50:50±5 (Lactide:Glycolide, by NMR)
lactide:glycolide 50:50

Quality Level

100

mol wt

PEG Mn 4000-6000 g/mol (by NMR)
PEG average Mn 5,000
PLGA Mn 12000-18000 g/mol
PLGA average Mn 15,000

suitability

conforms to structure for NMR

storage temp.

−20°C

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Application

Maleimide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a maleimide-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the maleimide-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system.
Locatelli E, et al.
Journal of Nanoparticle Research, 14, 1316-1316 (2012)
Ilaria Monaco et al.
Journal of medicinal chemistry, 60(10), 4510-4516 (2017-05-05)
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact

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