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  • Solvent-free sonochemical preparation of alpha-aminophosphonates catalyzed by 1-hexanesulphonic acid sodium salt.

Solvent-free sonochemical preparation of alpha-aminophosphonates catalyzed by 1-hexanesulphonic acid sodium salt.

Ultrasonics sonochemistry (2010-03-17)
Kirti S Niralwad, Bapurao B Shingate, Murlidhar S Shingare
ABSTRACT

1-Hexanesulphonic acid sodium salt was found to be an efficient catalyst for the green synthesis of alpha-aminophosphonates by the coupling of aldehydes/ketone, an amine and triethyl phosphite under ultrasound irradiation at ambient temperature for appropriate time to furnish the desired product in good to excellent yield under solvent-free condition. This catalyst provides clean conversion; greater selectivity and easy workup make this protocol practical and economically attractive.

MATERIALS
Product Number
Brand
Product Description

Supelco
Sodium 1-hexanesulfonate monohydrate, suitable for ion pair chromatography, LiChropur, ≥99.0% (T)
Sigma-Aldrich
Sodium 1-hexanesulfonate monohydrate, ≥98.0% (T)
Supelco
Sodium 1-hexanesulfonate solution, suitable for ion pair chromatography, concentrate, LiChropur, ampule
Sigma-Aldrich
Sodium hexanesulfonate, ≥98% (elemental analysis)
Sigma-Aldrich
Sodium hexanesulfonate, BioXtra