SML0396

Tafenoquine succinate

≥95% (HPLC), primaquine analog, powder

• Synonym(s): N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine, SB-252263, WR 238605
• Empirical Formula (Hill Notation): C₂₄H₂₈F₃N₃O₃ · C₄H₆O₄
• CAS Number: 106635-81-8
• Molecular Weight: 581.58
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825392
• NACRES: NA.77
• MDL number: MFCD00892249
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: Tafenoquine succinate, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCC(O)=O.COc1cc(C)c2c(Oc3cccc(c3)C(F)(F)F)c(OC)cc(NC(C)CCCN)c2n1
• InChI: 1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
• InChI key: CQBKFGJRAOXYIP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.

Tafenoquine is an antimalarial.

Tafenoquine has been generally generated for oral administration and drug absorption increases when taken along with food. It is known to possess a longer half life.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable