M9191

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), female

• Synonym(s): lab equipment accessory
• NACRES: NA.47
• UNSPSC Code: 12161501
• Specific activity: ≥20 units/mg protein, pH 7.4, 37 °C
• Biological source: rat (Sprague-Dawley)

Properties

• biological source: rat (Sprague-Dawley)
• Quality Level: 200
• form: liquid
• specific activity: ≥20 units/mg protein, pH 7.4, 37 °C
• packaging: vial of ~10 mg
• shipped in: dry ice
• storage temp.: −70°C

Description

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Source of drug metabolizing enzymes, including cytochrome P-450.

Other Notes

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.
7-ethoxyresorufin O-deethylase activity: One unit will hydroxylate 1.0 picomole paclitaxel per minute at pH 7.4 at 37 deg C.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable