- Microbial metabolites of harman alkaloids.
Microbial metabolites of harman alkaloids.
Chemical & pharmaceutical bulletin (2003-06-17)
Wimal Herath, Julie Rakel Mikell, Daneel Ferreira, Ikhlas Ahmad Khan
PMID12808240
ABSTRACT
Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7).