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D7008

Sigma-Aldrich

Dihydroethidium

≥95% purity, powder

Synonym(s):

2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine, Hydroethidine

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About This Item

Empirical Formula (Hill Notation):
C21H21N3
CAS Number:
104821-25-2
Molecular Weight:
315.41
Beilstein:
5107482
MDL number:
MFCD00077335
UNSPSC Code:
12171500
PubChem Substance ID:
24894069
NACRES:
NA.47

product name

Dihydroethidium, ≥95%

Quality Level

100

Assay

≥95%

form

powder

technique(s)

titration: suitable

color

pink to very dark red

solubility

chloroform: 20 mg/mL

fluorescence

λex 370 nm; λem 420 nm (for cytoplasm of living cells)
λex 535 nm; λem 610 nm (for chromatin of living cells)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

SMILES string

CCN1C(c2ccccc2)c3cc(N)ccc3-c4ccc(N)cc14

InChI

1S/C21H21N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,21H,2,22-23H2,1H3

InChI key

XYJODUBPWNZLML-UHFFFAOYSA-N

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Related Categories

Application

Redox indicator. Blue fluorescence until oxidized to ethidium.
Dihydroethidium has been used as a superoxide probe in bovine pulmonary artery endothelial cell (BPAEC). It has been used to check the in situ generation of ROS (reactive oxygen species).

Packaging

Packaged under Argon.

Linkage

B-ring reduced analog of ethidium

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV6154
MKCS1183
MKCQ9818
MKCN1192
MKCL7544

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Cira Rubies et al.
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20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
Medhora M, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 294, L902-L911 (2008)
Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm.
Wang L, et al.
Molecular Medicine Reports, 9, 435-442 (2014)
Rossarin Suwanarusk et al.
The Journal of antimicrobial chemotherapy, 70(1), 124-129 (2014-08-26)
Methylene blue, once discarded due to its unsettling yet mild side effects, has now found a renewed place in the pharmacopoeia of modern medicine. The continued spread of drug-resistant Plasmodium vivax and Plasmodium falciparum has also led to a recent
Karina A Roth et al.
Journal of endodontics, 38(9), 1253-1256 (2012-08-16)
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Articles

Mitochondrial Stress and ROS

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

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