SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms:
NCX1
Species:
Human SLC8A1 (6546), Mouse Slc8a1 (20541), Rat Slc8a1 (29715), domestic cat SLC8A1 (493807), domestic guinea pig Slc8a1 (100135620), chicken SLC8A1 (395760), dog SLC8A1 (493808), dog SLC8A1 (475738), naked mole-rat Slc8a1 (101711105), Horse SLC8A1 (100034157) ...More
UniProtKB ID:
Gene ID:
- Human(6546) Summary: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
- Mouse(20541) solute carrier family 8 (sodium/calcium exchanger), member 1
- Rat(29715) solute carrier family 8 (sodium/calcium exchanger), member 1
- domestic cat(493807) solute carrier family 8 (sodium/calcium exchanger), member 1
- domestic guinea pig(100135620) solute carrier family 8 (sodium/calcium exchanger), member 1
- chicken(395760) solute carrier family 8 (sodium/calcium exchanger), member 1
- dog(493808) solute carrier family 8 (sodium/calcium exchanger), member 1
- dog(475738) solute carrier family 8 (sodium/calcium exchanger), member 1
- naked mole-rat(101711105) solute carrier family 8 (sodium/calcium exchanger), member 1
- Horse(100034157) solute carrier family 8 (sodium/calcium exchanger), member 1
- cow(337925) solute carrier family 8 (sodium/calcium exchanger), member 1
- Domestic Rabbit(100328570) solute carrier family 8 (sodium/calcium exchanger), member 1
- sheep(101116716) solute carrier family 8 (sodium/calcium exchanger), member 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Sodium-Calcium Exchanger 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
western blot
western blot
Anti-SLC8A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse, clone C2C12,
Species Reactivity
canine, guinea pig, human, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
ANTI-SLC8A1 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot