JAK1
Janus kinase 1
Synonyms:
JAK1A, JAK1B, JTK3
Species:
Human JAK1 (3716), Mouse Jak1 (16451), Rat Jak1 (84598), naked mole-rat Jak1 (101710283), domestic guinea pig Jak1 (100726895), Domestic Rabbit JAK1 (100352594), sheep JAK1 (101110716), domestic cat JAK1 (101084377), Horse JAK1 (100054008), cow JAK1 (537201) ...More
UniProtKB ID:
Gene ID:
- Human(3716) Summary: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
- Mouse(16451) Janus kinase 1
- Rat(84598) Janus kinase 1
- naked mole-rat(101710283) Janus kinase 1
- domestic guinea pig(100726895) Janus kinase 1
- Domestic Rabbit(100352594) Janus kinase 1
- sheep(101110716) Janus kinase 1
- domestic cat(101084377) Janus kinase 1
- Horse(100054008) Janus kinase 1
- cow(537201) Janus kinase 1
- dog(442952) Janus kinase 1
- Zebrafish(30280) Janus kinase 1
- chicken(395681) Janus kinase 1
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-JAK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-JAK1 Antibody, clone 73, clone 73, from mouse,
Species Reactivity
xenopus, canine, chicken, human, mouse, rat
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Phospho-Jak1-Y1022/1023 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
Jak1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Species
human
JAK1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.,
Species
human