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Merck

ADAM22

ADAM metallopeptidase domain 22

Synonyms:
ADAM 22, MDC2
Species:
UniProtKB ID:
Gene ID:
  • Human(53616) Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
  • Mouse(11496) a disintegrin and metallopeptidase domain 22
  • Rat(57033) ADAM metallopeptidase domain 22
  • domestic guinea pig(100727244) ADAM metallopeptidase domain 22
  • Zebrafish(100240727) a disintegrin and metallopeptidase domain 22
  • chicken(420537) ADAM metallopeptidase domain 22
  • domestic cat(101098366) ADAM metallopeptidase domain 22
  • Horse(100050380) ADAM metallopeptidase domain 22
  • naked mole-rat(101704879) ADAM metallopeptidase domain 22
  • dog(482286) ADAM metallopeptidase domain 22
  • Domestic Rabbit(100338906) ADAM metallopeptidase domain 22
  • cow(523645) ADAM metallopeptidase domain 22
  • sheep(101116564) ADAM metallopeptidase domain 22

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human ADAM-22 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ADAM22 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Adam22,
Species
mouse
MISSION® esiRNA, targeting human ADAM22,
Species
human