ADAM22
ADAM metallopeptidase domain 22
ADAM 22, MDC2
Human ADAM22 (53616), Mouse Adam22 (11496), Rat Adam22 (57033), domestic guinea pig Adam22 (100727244), Zebrafish adam22 (100240727), chicken ADAM22 (420537), domestic cat ADAM22 (101098366), Horse ADAM22 (100050380), naked mole-rat Adam22 (101704879), dog ADAM22 (482286) ...More
- Human(53616) Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
- Mouse(11496) a disintegrin and metallopeptidase domain 22
- Rat(57033) ADAM metallopeptidase domain 22
- domestic guinea pig(100727244) ADAM metallopeptidase domain 22
- Zebrafish(100240727) a disintegrin and metallopeptidase domain 22
- chicken(420537) ADAM metallopeptidase domain 22
- domestic cat(101098366) ADAM metallopeptidase domain 22
- Horse(100050380) ADAM metallopeptidase domain 22
- naked mole-rat(101704879) ADAM metallopeptidase domain 22
- dog(482286) ADAM metallopeptidase domain 22
- Domestic Rabbit(100338906) ADAM metallopeptidase domain 22
- cow(523645) ADAM metallopeptidase domain 22
- sheep(101116564) ADAM metallopeptidase domain 22
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