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C4292

Sigma-Aldrich

Cefoperazone sodium salt

870 - 1015 μg/mg anhydrous basis

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About This Item

Empirical Formula (Hill Notation):
C25H26N9NaO8S2
CAS Number:
62893-20-3
Molecular Weight:
667.65
Beilstein:
4902135
EC Number:
263-751-5
MDL number:
MFCD07793331
UNSPSC Code:
51102829
PubChem Substance ID:
24892686
NACRES:
NA.85

Assay

870-1015 μg/mg (anhydrous basis)

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c5ccc(O)cc5)C(=O)C1=O

InChI

1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1

InChI key

NCFTXMQPRQZFMZ-WERGMSTESA-M

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General description

Chemical structure: ß-lactam

Application

Cefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.

Biochem/physiol Actions

Cefoperazone exerts its bactericidal effect by inhibiting the mucopeptide synthesis that affects the structure of bacterial cell wall. It has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Precautionary Statements

P261 - P280 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B Gonik et al.
Antimicrobial agents and chemotherapy, 30(6), 874-876 (1986-12-01)
Limited pharmacokinetic data for cefoperazone are available from the parturient. Because cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney, pregnancy-induced physiologic alterations can influence its deposition and clearance. Twelve term parturients receiving
A Meulemans
Antimicrobial agents and chemotherapy, 36(2), 295-298 (1992-02-01)
The apparent diffusion coefficient of a bound drug, cefoperazone, was studied. The protein binding of cefoperazone was studied by voltammetry, a technique which permitted instant measurements. The apparent diffusion coefficients were similar in agar and fibrin and lower in rat
M Ugarte-Ruiz et al.
Journal of applied microbiology, 113(1), 200-208 (2012-04-27)
To identify the optimal method for detection of thermophilic Campylobacter at various stages in the food chain, three culture-dependent (direct plating, Bolton and Preston enrichment) and one molecular method (qPCR) were compared for three matrices: poultry faeces (n = 38), neck skin
Christopher Staley et al.
Microbiome, 5(1), 87-87 (2017-08-02)
Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the recipient intestine, which
Katie L Mason et al.
Infection and immunity, 80(1), 150-158 (2011-10-12)
The indigenous bacterial microbiome of the stomach, including lactobacilli, is vital in promoting colonization resistance against Candida albicans. However, there are gaps in our understanding about C. albicans gastric colonization versus disease, especially during the postantibiotic recovery phase. This study
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