869006-M

Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade

• Synonym(s): Thyroid Stimulating Hormone, Human Pituitary, Iodination Grade, Thyrotropin, hTSH
• CAS Number: 9002-71-5
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human pituitary glands
• Quality Level: 100
• sterility: non-sterile
• Assay: ≥95% (weight)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• technique(s): enzyme immunoassay: suitable
• impurities: ≤0.1% hPRL (weight); ≤0.2% hGH, hFSH (weight); ≤0.3% hLH (weight)
• solubility: 0.05 M PBS: 1 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... TSHB(7252)

Description

General description

Research area: Cell Signaling

Thyroid Stimulating Hormone is a glycoprotein produced by anterior pituitary gland. Its structure contains an alpha chain and a beta chain.

Biochem/physiol Actions

Thyroid stimulating hormone It exerts mild, continuous stimulation on the thyroid, resulting in maintenance of activity. TSH modulates the release of T3 and T4 from thyroid follicular cells. Thyroid Stimulating Hormone (TSH) primary targets thyroid gland and maintains thyroid activity. It regulates the release of T3 and T4 hormones from thyroid follicular cells. TSH binds to the TSH receptor (TSHR) and trigger Gs and Gq pathways. Activation of the Gs pathway stimulates iodide uptake, hormone secretion, and gland growth. The Gq pathway is involved in iodide organification for hormone synthesis. TSH secretion is inhibited by Somatostatin. Overexpression of TSH leads to hyperthyroidism, whereas lower TSH expression leads to hypothyroidism.

Warning

Toxicity: Standard Handling (A)

Unit Definition

1mg/ml in 0.05M PBS

Preparation Note

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable