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  • A New Derivatization Reagent for HPLC-MS Analysis of Biological Organic Acids.

A New Derivatization Reagent for HPLC-MS Analysis of Biological Organic Acids.

Chromatographia (2017-12-08)
Bryce J Marquis, Hayley P Louks, Chhanda Bose, Robert R Wolfe, Sharda P Singh
ABSTRACT

Small molecules containing carboxylic acid functional groups are ubiquitous throughout biology, playing vital roles in biological chemistry ranging from energy metabolism to cellular signaling. This paper describes a new derivatization reagent, 4-bromo-

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
N-Ethylmethylamine, 97%
Sigma-Aldrich
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97.0% (T)
Sigma-Aldrich
Methylmalonic acid, 99%