- L-Satropane Prevents Retinal Neuron Damage by Attenuating Cell Apoptosis and Aβ Production via Activation of M1 Muscarinic Acetylcholine Receptor.
L-Satropane Prevents Retinal Neuron Damage by Attenuating Cell Apoptosis and Aβ Production via Activation of M1 Muscarinic Acetylcholine Receptor.
Current eye research (2017-06-21)
Ping Yu, Wei Zhou, Lu Liu, Ya-Bin Tang, Yun Song, Juan-Juan Lu, Li-Na Hou, Hong-Zhuan Chen, Yong-Yao Cui
PMID28632409
ABSTRACT
Muscarinic acetylcholine receptor (mAChR) agonists have been used to treat glaucoma due to their intraocular pressure-lowering effects. Recently, it has been reported that retinal mAChRs activation can also stimulate neuroprotective pathways. In our study, we evaluated the potential neuroprotective effect of L-satropane, a novel mAChR agonist, on retinal neuronal injury induced by cobalt chloride (CoCl CoCl Pretreatment with L-satropane protects against CoCl These results demonstrated that L-satropane might be effective in preventing retinal neuron damage caused by CoCl