Excretion characteristics of tetrabromobisphenol-A in Wistar rats following mouth and nose inhalation exposure.

Tetrabromobisphenol-A (TBBPA), a brominated flame retardant with the largest production volume worldwide, is employed as a reactive and additive flame retardant, and also as an intermediate in the production of other retardants. The constant release of TBBPA into the environment has attracted increasing attention to its potent health effects. To date, the vast majority of health-related research on TBBPA has focused on oral exposure. This study aims to explore the excretion characteristics of TBBPA in living organisms following inhalation exposure. An inhalation exposure system was established in which the experimental animal model was exposed to inhalable particles (diameter < 10 μm) of TBBPA. The TBBPA aerosol doses used were 12.9, 54.6, 121.6, and 455.0 mg/m