Skip to Content
Merck
  • Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Journal of controlled release : official journal of the Controlled Release Society (2010-07-21)
Janine Jansen, Mark J Boerakker, Jean Heuts, Jan Feijen, Dirk W Grijpma
ABSTRACT

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

MATERIALS
Product Number
Brand
Product Description

Supelco
Vinyl acetate solution, certified reference material, 5000 μg/mL in acetonitrile
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
mono-Ethyl fumarate, 95%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Vinyl acetate, contains 3-20 ppm hydroquinone as inhibitor, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Vinyl acetate, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Supelco
Vinyl acetate, analytical standard
SKU
Pack Size
Availability
Price
Quantity