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  • Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

Organic letters (2002-07-06)
Vito Capriati, Saverio Florio, Renzo Luisi, Antonio Salomone
ABSTRACT

[reaction: see text] The stereospecific alpha-lithiation of optically active styrene oxides and the trapping reaction of the corresponding highly reactive intermediates with electrophiles to produce optically active styrene oxide derivatives are described. This methodology has been applied to the synthesis of an optically active oral antifungal agent of industrial interest.

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Lithium aluminum hydride solution, 2.3 M in 2-methyltetrahydrofuran
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Lithium aluminum hydride, ≥97.0% (gas-volumetric), tablet (5 g each)
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Lithium aluminum hydride, ≥97.0% (gas-volumetric)
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100 μL
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€536.00
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Lithium aluminum hydride, hydrogen-storage grade
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100 μL
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€536.00
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Lithium aluminum hydride solution, 0.5 M in 2-methoxyethyl ether
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100 μL
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Lithium aluminum hydride, pellets, reagent grade, 95%
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100 μL
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Lithium aluminum hydride solution, 1.0 M in diethyl ether
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100 μL
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Lithium aluminum hydride solution, 2.0 M in THF
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100 μL
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€536.00
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Lithium aluminum hydride, powder, reagent grade, 95%
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100 μL
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€536.00
Sigma-Aldrich
Lithium aluminum hydride solution, 1.0 M in THF
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100 μL
1 Estimated to ship on 21 February 2025
€536.00