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199338

Sigma-Aldrich

1,4-Diamino-2-butanone dihydrochloride

99%

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About This Item

Linear Formula:
H2NCH2CH2COCH2NH2 · 2HCl
CAS Number:
3660-09-1
Molecular Weight:
175.06
EC Number:
222-914-0
MDL number:
MFCD00012908
UNSPSC Code:
12352100
PubChem Substance ID:
24851907
NACRES:
NA.22

Assay

99%

mp

221 °C (dec.) (lit.)

functional group

amine
ketone

SMILES string

Cl[H].Cl[H].NCCC(=O)CN

InChI

1S/C4H10N2O.2ClH/c5-2-1-4(7)3-6;;/h1-3,5-6H2;2*1H

InChI key

HDRKYQXFDHZZOW-UHFFFAOYSA-N

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Application

1,4-Diamino-2-butanone dihydrochloride was used as a media supplement for the growth of B.pertussis and B. bronchiseptica[1].

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
05210JQ
12411JG
07909MB

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Ana F Garcia et al.
Infection and immunity, 73(5), 2602-2610 (2005-04-23)
Trichomonas vaginalis secretes putrescine that is readily detected in vaginal secretions. We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarboxylase (ODC) on T. vaginalis. One reason is because inhibition of Tritrichomonas foetus ODC results
M Martinez-Pacheco et al.
Archives of microbiology, 151(1), 10-14 (1989-01-01)
Diamino butanone (DAB), a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon. Addition of DAB
T J Brickman et al.
Journal of bacteriology, 178(1), 54-60 (1996-01-01)
Chromosomal insertions defining Bordetella bronchiseptica siderophore phenotypic complementation group III mutants BRM3 and BRM5 were found to reside approximately 200 to 300 bp apart by restriction mapping of cloned genomic regions associated with the insertion markers. DNA hybridization analysis using
D Guzmán-de-Peña et al.
Fungal genetics and biology : FG & B, 21(2), 198-205 (1997-04-01)
Regulation of aflatoxin biosynthesis during differentiation of Aspergillus parasiticus was analyzed by using a drug that inhibits the development of the fungus and mutants affected in sporulation. Diaminobutanone, a competitive inhibitor of ornithine decarboxylase, repressed spore germination. If added after
D Menezes et al.
Parasitology research, 98(2), 99-105 (2005-11-12)
Trypanosoma cruzi is the etiological agent of American trypanosomiasis. Most of the available data on trypanosomatid parasites were obtained from African trypanosomes. Parasitic protozoa polyamine metabolism and transport pathways comprise valuable targets for chemotherapy. T. cruzi cannot synthesize putrescine, but
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