INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa
Synonyms:
CORS1, CPD4, JBTS1, MORMS, PPI5PIV
Species:
Human INPP5E (56623), Mouse Inpp5e (64436), Rat Inpp5e (114089), naked mole-rat Inpp5e (101701719), sheep INPP5E (101115530), dog INPP5E (607443), domestic guinea pig Inpp5e (100715053), chicken INPP5E (417135), domestic cat INPP5E (101093901), Zebrafish inpp5e (606579)
UniProtKB ID:
Gene ID:
- Human(56623) Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
- Mouse(64436) inositol polyphosphate-5-phosphatase E
- Rat(114089) inositol polyphosphate-5-phosphatase E
- naked mole-rat(101701719) inositol polyphosphate-5-phosphatase, 72 kDa
- sheep(101115530) inositol polyphosphate-5-phosphatase, 72 kDa
- dog(607443) inositol polyphosphate-5-phosphatase, 72 kDa
- domestic guinea pig(100715053) inositol polyphosphate-5-phosphatase, 72 kDa
- chicken(417135) inositol polyphosphate-5-phosphatase, 72 kDa
- domestic cat(101093901) inositol polyphosphate-5-phosphatase, 72 kDa
- Zebrafish(606579) inositol polyphosphate-5-phosphatase
- cow(506349) inositol polyphosphate-5-phosphatase, 72 kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-INPP5E antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-INPP5E antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot