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Merck

DRD4

dopamine receptor D4

Synonyms:
D4DR
Species:
UniProtKB ID:
Gene ID:
  • Human(1815) Summary: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
  • Mouse(13491) dopamine receptor D4
  • Rat(25432) dopamine receptor D4
  • naked mole-rat(101708437) dopamine receptor D4
  • dog(448805) dopamine receptor D4
  • domestic guinea pig(100733356) dopamine receptor D4
  • dog(607223) dopamine receptor D4
  • chicken(423016) dopamine receptor D4

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Small Molecule - Agonist

Product Number
Description
Species
PD 168,077 maleate salt, powder,
Species
human
Apomorphine hydrochloride hemihydrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Pramipexole dihydrochloride, >98% (HPLC), powder,
Species
human
Ropinirole hydrochloride, powder, ≥98% (HPLC),
Species
human
Ropinirole hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
U-101958 maleate salt, solid,
Species
human
L-745,870 hydrochloride, ,
Species
human
L-741,626, ≥98% (HPLC),
Species
human
Chlorpromazine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Droperidol, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Drd4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-DRD4 Antibody, clone 2B9, clone 2B9, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
Anti-Dopamine D4 Receptor Antibody, extracellular domain, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
Anti-Dopamine D₄ Receptor Rabbit pAb, lyophilized, Calbiochem®,
Species Reactivity
human, rat
Application

Small Molecule - Inhibitor

Product Number
Description
Species
GBR 12909 dihydrochloride, solid, ≥98% (HPLC),
Species
human
Bupropion hydrochloride, ≥98% (HPLC), solid,
Species
human
Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Amoxapine, 1.0 mg/mL in methanol, certified reference material, Cerilliant®,
Species
human
Amoxapine, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
3-Methoxytyramine hydrochloride, ≥95.5%, crystalline,
Species
human
3-Hydroxy-4-methoxyphenethylamine hydrochloride, ,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
BP897, >98% (HPLC), solid,
Species
human, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
3,4-Dihydroxy-DL-phenylalanine, ,
Species
mouse, human, rat
3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC),
Species
mouse, human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Drd4,
Species
mouse