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ASPH

aspartate beta-hydroxylase

Synonyms:
AAH, BAH, CASQ2BP1, HAAH, JCTN, junctin
Species:
Human ASPH (444), Mouse Asph (65973), Rat Asph (312981), domestic cat ASPH (101100695), dog ASPH (403846), naked mole-rat Asph (101725986), Zebrafish asph (323659), cow ASPH (286771), domestic guinea pig Asph (100726813), Horse ASPH (100065909) ...More
UniProtKB ID:
Q12797, A6NDF4, A6NHI2, B4DIC9, B4E2K4, B7ZM95, E5RGP5, F5H667
Gene ID:
  • Human(444) Summary: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. [provided by RefSeq, Sep 2009]
  • Mouse(65973) aspartate-beta-hydroxylase
  • Rat(312981) aspartate-beta-hydroxylase
  • domestic cat(101100695) aspartate beta-hydroxylase
  • dog(403846) aspartate beta-hydroxylase
  • naked mole-rat(101725986) aspartate beta-hydroxylase
  • Zebrafish(323659) aspartate beta-hydroxylase
  • cow(286771) aspartate beta-hydroxylase
  • domestic guinea pig(100726813) aspartate beta-hydroxylase
  • Horse(100065909) aspartate beta-hydroxylase
  • chicken(421142) aspartate beta-hydroxylase
  • fruit fly(36778) Aspartyl beta-hydroxylase

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2105140
Anti-ASPH, (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
HPA055161
Anti-ASPH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
SAB2108625
Anti-ASPH, affinity isolated antibody,
Species Reactivity
dog, human, rat
Application
western blot
HPA059303
Anti-ASPH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
EHU068341
MISSION® esiRNA, targeting human ASPH,
Species
human