No evidence for association of

5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the In 303 placentas screened for this study, we observed no significant association between the occurrence of NTDs ( We conclude that large-scale, genome-wide disruption in DNAm does not occur in placentas with the high-risk