Direkt zum Inhalt
Merck

Seizures associated with ofloxacin therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (1995-12-01)
S M Traeger, M F Bonfiglio, J A Wilson, B R Martin, N A Nackes
ZUSAMMENFASSUNG

We describe four patients who had seizures while receiving ofloxacin; no other causes were evident. Common factors among all patients included advanced age and use of a high-dose regimen. The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor. Other potentially related factors included electrolyte abnormalities and prior neurological insult. Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Ofloxacin, fluoroquinolone antibiotic
USP
Ofloxacin, United States Pharmacopeia (USP) Reference Standard
Supelco
Ofloxacin, Pharmaceutical Secondary Standard; Certified Reference Material
Ofloxacin, European Pharmacopoeia (EP) Reference Standard
Supelco
Ofloxacin, VETRANAL®, analytical standard