- Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Bioorganic & medicinal chemistry letters (2007-04-17)
Steven W Kortum, Timothy E Benson, Michael J Bienkowski, Thomas L Emmons, D Bryan Prince, Donna J Paddock, Alfredo G Tomasselli, Joseph B Moon, Alice LaBorde, Ruth E TenBrink
PMID17434734
ZUSAMMENFASSUNG
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.