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  • Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.

Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates.

Chemical communications (Cambridge, England) (2013-08-01)
Takayoshi Arai, Yuta Ogino, Toru Sato
ZUSAMMENFASSUNG

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethine imines with propiolates. The PyBodine(l-Ala)-Cu(OAc)2 catalyst was selected on the basis of solid-phase catalysis/CD-HTS and exhibited high efficiency, producing the (R)-adducts with excellent enantioselectivity.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Pyridin, ACS reagent, ≥99.0%
Sigma-Aldrich
Pyridin, suitable for HPLC, ≥99.9%
Sigma-Aldrich
Pyridin, anhydrous, 99.8%
Sigma-Aldrich
Propiolsäure, 95%
Sigma-Aldrich
Pyridin -hydrochlorid, 98%
Sigma-Aldrich
Pyridin, ≥99%
Sigma-Aldrich
Pyridin, biotech. grade, ≥99.9%
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Pyridin -hydrobromid, 98%
Supelco
Pyridin, analytical standard
Supelco
Pyridin -Lösung, certified reference material, 2000 μg/mL in methanol
Sigma-Aldrich
Pyridin -hydrochlorid, purum, ≥98.0% (AT)