- Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.
Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.
Bioorganic & medicinal chemistry letters (2004-03-12)
Elizabeth Joshi, Mahendra D Chordia, Timothy L Macdonald, Joel Linden, Ray Olsson
PMID15012996
ZUSAMMENFASSUNG
Solutions of 2-amino-3-aroyl-4,5-dialkylthiophenes in DMSO (dimethyl sulfoxide) undergo regioselective oxidation of benzylic carbon under mild conditions. We describe three examples and propose a mechanism for oxidation.