- [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound].
[Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2013-04-20)
E Zhang, Rui Tan, Jian Gu, Li-Li He, Feng Yao
PMID23596875
ZUSAMMENFASSUNG
To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets. Drug release profiles in vitro were affected obviously by membrane thickness, penetrating agents and porogen. Membrane controlled tablets of puerarin inclusion compound were prepared according to the optimal formulation with zero-order kinetics.