Direkt zum Inhalt
Merck

Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots.

Bioorganic & medicinal chemistry letters (2005-06-18)
Woo Song Lee, Mi Jeong Kim, Young-Il Beck, Yong-Dae Park, Tae-Sook Jeong
ZUSAMMENFASSUNG

(R)-Glycerol-monolinoleate 4 and (R)-glycerol-monostearate 5 were isolated from the ethyl acetate extracts of Saururus chinensis roots and (R)- or (S)-fatty acid glycerols 4 and 5 were synthesized for confirming their structures and evaluating their inhibitory activities against Lp-PLA(2). The (R)-4 and (S)-4 exhibited Lp-PLA(2) inhibitory activities with IC(50) values of 45.0 and 52.0 microM, respectively.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
1-Linoleoyl-rac-glycerol, ≥97%, liquid
Glycerin-monolinolat, European Pharmacopoeia (EP) Reference Standard