- Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.
Bioorganic & medicinal chemistry letters (2005-05-07)
Robert E McDevitt, Michael S Malamas, Eric S Manas, Rayomand J Unwalla, Zhang B Xu, Chris P Miller, Heather A Harris
PMID15876535
ZUSAMMENFASSUNG
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
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