SML3459
RBPJ Inhibitor-1
≥98% (HPLC)
Synonym(e):
2-(2-Fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)-benzamide, RIN1
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C17H14FN3O2
CAS-Nummer:
Molekulargewicht:
311.31
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.77
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Qualitätsniveau
Assay
≥98% (HPLC)
Form
powder
Farbe
white to beige
Löslichkeit
DMSO: 2 mg/mL, clear
Lagertemp.
-10 to -25°C
Biochem./physiol. Wirkung
RBPJ Inhibitor-1 (RIN1) is a selective inhibitor against the transcription factor RBPJ. RIN1 blocks RBPJ-SHARP transcriptional repressor complex formation, inhibits RBPJ-mediated Notch intracellular domain (NICD) transcription activity (IC50/Emax = 180 nM/82% and 190 nM/88% using Notch2 ICD or Notch3 ICD, respectively), as well as NICD-independent transcription activity of RBPJ-VP16 (IC50 = 200 nM, Emax = 81%). RIN1 inhibits Notch-driven cancer proliferation (by ~70% post 4-day 10 μM RIN1 treatment; Jurkat) and promotes muscle differentiation (0.6 μM for 4 days; C2C12 myoblasts).
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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