SML0761

Gossypin

≥90% (HPLC)

• Synonym(e): 3,3′,4′,5,7,8-Hexahydroxyflavon-8-glucosid
• Empirische Formel (Hill-System): C₂₁H₂₀O₁₃
• CAS-Nummer: 652-78-8
• Molekulargewicht: 480.38
• MDL-Nummer: MFCD00017429
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825593
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: Hibiscus vitifolius
• Assay: ≥90% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: , light yellow to dark green-yellow
• Löslichkeit: DMSO: 15 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
• InChIKey: SJRXVLUZMMDCNG-KKPQBLLMSA-N

Beschreibung

Allgemeine Beschreibung

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

Biochem./physiol. Wirkung

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable