Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

SML0508

Sigma-Aldrich

Pentostatin

≥95% (HPLC)

Synonym(e):

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C11H16N4O4
CAS-Nummer:
53910-25-1
Molekulargewicht:
268.27
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825517
NACRES:
NA.77

Assay

≥95% (HPLC)

Form

powder

Optische Aktivität

[α]/D +70 to +80°, c = 1 in H2O

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

H2O: 10 mg/mL, clear

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChIKey

FPVKHBSQESCIEP-JQCXWYLXSA-N

Angaben zum Gen

human ... ADA(100)

Anwendung

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Biochem./physiol. Wirkung

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

Leistungsmerkmale und Vorteile

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sonstige Hinweise

Air sensitve; hygroscopic.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 5

1 of 5

Cordycepin from Cordyceps militaris

Sigma-Aldrich

C3394

Cordycepin

Adenosin-5′-(α,β-methylen)diphosphat ADP analog

Sigma-Aldrich

M3763

Adenosin-5′-(α,β-methylen)diphosphat

Adenosin suitable for cell culture, BioReagent

Sigma-Aldrich

A4036

Adenosin

Inosin ≥99% (HPLC)

Sigma-Aldrich

I4125

Inosin

Adenosin ≥99%

Sigma-Aldrich

A9251

Adenosin

Behrouz Elahi et al.
Colloids and surfaces. B, Biointerfaces, 181, 830-836 (2019-06-30)
Bio-based synthesis of Nano-Ceria (NC) was performed in Linum usitatissimum L. (Lu) seeds extract as capping agent. Obtained gel was calcined at 400, 500, and 600 °C to investigate the effect of temperature on the size and morphology of the particles.
Da-Tong Ju et al.
Nutrients, 11(7) (2019-07-25)
Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viability
Youliang Zhao et al.
Environmental toxicology and pharmacology, 70, 103201-103201 (2019-06-16)
Early and accurate evaluation of immunotoxicity is crucial. However, there are few in vitro models for immunosuppressive evaluation. THP-1 cells has long been used for in vitro sensitivity evaluation. Whether it can be used for immunosuppressive evaluation remains unclear. In
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).
Spiers AS, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)
Solid tumor therapy by selectively targeting stromal endothelial cells
Liu S, et al.
Proceedings of the National Academy of Sciences of the USA, 113(28), E4079-E4087 (2016)
Alle zugehörigen Dokumente anzeigen

Artikel

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.