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SAB2500236

Sigma-Aldrich

Anti-Choline acetyltransferase antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-Acetyl CoA:choline O-acetyltransferase, Anti-CHAT, Anti-CMS1A, Anti-CMS1A2

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About This Item

MDL-Nummer:
MFCD01321843
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

goat

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

canine, chimpanzee, human, pig

Methode(n)

indirect ELISA: suitable
western blot: suitable

UniProt-Hinterlegungsnummer

P28329

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CHAT(1103)

Allgemeine Beschreibung

Choline acetyltransferase (CHAT) has a molecular weight of about 68kDa. It is synthesized in the parakaryon and is transported to the axon terminals. CHAT is part of the choline/carnitine acyltransferase family.

Immunogen

Peptide with sequence CKEKATRPSQGHQP from the C Terminus of the protein sequence according to NP_065574; NP_066264; NP_066265; NP_066266.

Biochem./physiol. Wirkung

Choline acetyltransferase (CHAT) is involved in the synthesis of acetylcholine in neurons. It catalyzes the transfer of an acetyl group between acetyl-coenzyme A and choline. Mutations in the gene encoding this protein have been associated with congenital neuromuscular disorders.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders
The Embo Journal (2004)
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Olofsson PS, e.al
Nature Biotechnology (2016)
Francesco Antoniani et al.
Cell death discovery, 9(1), 248-248 (2023-07-16)
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The critical genetic players of ALS and FTD are the TARDBP, FUS and C9orf72 genes, whose protein products, TDP-43, FUS and

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