M5435

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

• Synonym(e): MPEP hydrochloride
• Empirische Formel (Hill-System): C₁₄H₁₁N · HCl
• CAS-Nummer: 219911-35-0
• Molekulargewicht: 229.70
• MDL-Nummer: MFCD02262119
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278557
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to light tan
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: Cl.Cc1cccc(n1)C#Cc2ccccc2
• InChI: 1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
• InChIKey: PKDHDJBNEKXCBI-UHFFFAOYSA-N
• Angaben zum Gen: human ... GRIN2B(2904) , GRM5(2915) ; rat ... Grm5(24418)

Beschreibung

Allgemeine Beschreibung

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.

Anwendung

6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).

Biochem./physiol. Wirkung

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).

Highly selective, non-competitive mGluR₅ metabotropic glutamate receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)