H1142

(15S,5Z,8Z,11Z,13E)-15-Hydroxy-eicosatetraensäure -Lösung

~150 μg/mL in ethanol, ≥97.0% (HPLC)

• Synonym(e): (S)-15-HETE
• Empirische Formel (Hill-System): C₂₀H₃₂O₃
• CAS-Nummer: 54845-95-3
• Molekulargewicht: 320.47
• Beilstein: 2470466
• MDL-Nummer: MFCD00063590
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24895431

Eigenschaften

• Assay: ≥97.0% (HPLC)
• Konzentration: ~150 μg/mL in ethanol
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
• InChIKey: JSFATNQSLKRBCI-VAEKSGALSA-N

Beschreibung

Biochem./physiol. Wirkung

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H315,H319,H335
• P-Sätze: P210 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 57.2 °F - closed cup
• Flammpunkt (°C): 14 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter