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B2050

Sigma-Aldrich

3-Bromo-7-nitroindazole

≥98% (TLC), powder

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About This Item

Empirische Formel (Hill-System):
C7H4BrN3O2
CAS-Nummer:
74209-34-0
Molekulargewicht:
242.03
MDL-Nummer:
MFCD00159910
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278258

Assay

≥98% (TLC)

Form

powder

Farbe

light yellow

Löslichkeit

ethanol: 25 mg/mL
DMSO: soluble

Lagertemp.

2-8°C

SMILES String

[O-][N+](=O)c1cccc2c(Br)n[nH]c12

InChI

1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)

InChIKey

NFSTZPMYAZRZPC-UHFFFAOYSA-N

Biochem./physiol. Wirkung

A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinson′s disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Saurav Bhowmick et al.
Free radical biology & medicine, 113, 203-211 (2017-10-01)
Cerebral ischemia-reperfusion (I/R) injury initiates a cascade of events, generating nitric oxide (NO) and superoxide(O
K Wada et al.
Journal of neurosurgery, 89(5), 807-818 (1998-11-17)
Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains to be clarified. The authors investigated alterations in constitutive nitric
N E Stagliano et al.
Brain research, 759(1), 32-40 (1997-06-06)
Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the
M J O'Neill et al.
Brain research, 760(1-2), 170-178 (1997-06-20)
Recent studies have shown that the novel antioxidant LY231617 protects against ischaemia-induced neuronal damage in rat models of global cerebral ischaemia. In the present studies we have examined the effects of LY231617 in the gerbil model of global cerebral ischaemia.
P A Bland-Ward et al.
Life sciences, 57(11), PL131-PL135 (1995-01-01)
The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung from endotoxin-pretreated rats was investigated. 3-bromo 7-nitro indazole was either
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