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Analysenzertifikate (CoA)/COQ

14-251-M

p38α/SAPK2a Protein, active, 10 µg

Name: p38α/SAPK2a Protein, active, 10 µg
Brand: MM

Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.

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About This Item

UNSPSC-Code:

12352202

eCl@ss:

32160405

NACRES:

NA.41

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Mol-Gew.

M_w 67.7 kDa

Hersteller/Markenname

Upstate^®

Methode(n)

activity assay: suitable (kinase)

Allgemeine Beschreibung

N-terminal GST tagged, recombinant, full length p38α/SAPK2a

Product Source: expressed in E. coli

Biochem./physiol. Wirkung

Protein Target: p38α/SAPK2a

Target Sub-Family: CMGC

Verpackung

Also available in 250μg size (2x125μg) - Call for pricing and availability. Please reference catalog number 14-251M when ordering the 250μg size.

Qualität

Routinely evaluated by phosphorylation of MBP

Physikalische Form

Glutathione-agarose

Lagerung und Haltbarkeit

6 months at -20°C

Sonstige Hinweise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Piktogramme

GHS07

Signalwort

Warning

H-Sätze

H317

P-Sätze

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

Y N Doza et al.

FEBS letters, 364(2), 223-228 (1995-05-08)

A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

Ben-Levy, R, et al.

The Embo Journal, 13, 3302-3311 (1994)

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.

A Cuenda et al.

FEBS letters, 364(2), 229-233 (1995-05-08)

A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)

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