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860466P

Avanti

N-C12-desoxymethylsphingosine

Avanti Research™ - A Croda Brand 860466P, powder

Synonym(e):

N-lauroyl-1-desoxymethylsphingosine (m17:1/12:0)

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About This Item

Empirische Formel (Hill-System):
C29H57NO2
CAS-Nummer:
1246298-55-4
Molekulargewicht:
451.77
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 1 mg (860466P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 860466P

Lipid-Typ

sphingolipids
bioactive lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[H][C@](/C=C/CCCCCCCCCCCCC)(O)CNC(CCCCCCCCCCC)=O

Allgemeine Beschreibung

Desoxymethylsphingosine is an atypical deoxy-sphingoid base.

Anwendung

N-C12-desoxymethylsphingosine or N-lauroyl-1-desoxymethylsphingosine (m17:1/12:0) has been used as a standard in the quantitation of atypical sphingoid bases in biological samples by reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-MS/MS).

Verpackung

5 mL Amber Glass Screw Cap Vial (860466P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Analysenzertifikate (COA)

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Michael S Marshall et al.
PloS one, 13(2), e0193438-e0193438 (2018-02-27)
α-Synuclein aggregation has been linked to Gaucher's disease (GD) and Krabbe's disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolipids in both conditions, specifically to increased galactosylsphingosine (psychosine) content in the
Michael S Marshall et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(3), 874-889 (2018-02-13)
We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is deficient in Krabbe's disease. When globally administered via intrathecal, intracranial, and intravenous injections to newborn mice affected with GALC deficiency
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that
Terina N Martinez et al.
Molecular neurodegeneration, 7, 45-45 (2012-09-15)
Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF) with
Sarah T Pruett et al.
Journal of lipid research, 49(8), 1621-1639 (2008-05-24)
"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now

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