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NanoFabTx™ for gene delivery
Azide lipid mix
Synonym(e):
Cholesterol, DMG-PEG, DODMA, DOPE, DOTMA, DSPE-PEG-Azide
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About This Item
UNSPSC-Code:
12352142
NACRES:
NA.21
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Lagertemp.
−20°C
Allgemeine Beschreibung
Azide lipid mix for gene delivery and targeted delivery
The NanoFabTx™ gene delivery azide lipid mix is a ready-to-use nanoformulation lipid mixture for the synthesis of aizde-functionalized lipid nanoparticles (LNPs).These lipid nanoparticles can be used for targeting and immunotherapy applications, and nucleic acid encapsulation.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of lipid nanoparticles. Step-by-step protocols for the synthesis of azide-functionalized LNPs by microfluidics with the NanoFabTx™ microfluidic- nano device kit (Cat. No. 911593) or nanoprecipitiation are included.
Azide-functionalized LNPs are advantageous for gene delivery because the azide functional group enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers or other biomolecules to the surface of the lipid nanoparticle via click chemistry. This surface modification enables mult-targeting or multi-cargo delivery to different cell types including immune cells.
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of lipid nanoparticles. Step-by-step protocols for the synthesis of azide-functionalized LNPs by microfluidics with the NanoFabTx™ microfluidic- nano device kit (Cat. No. 911593) or nanoprecipitiation are included.
Azide-functionalized LNPs are advantageous for gene delivery because the azide functional group enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers or other biomolecules to the surface of the lipid nanoparticle via click chemistry. This surface modification enables mult-targeting or multi-cargo delivery to different cell types including immune cells.
Anwendung
With the NanoFabTx™ gene delivery azide lipid mix, researchers can simplify their drug development workflow. The ready to use mix enables the screening of different drug modalities such as oligonucleotides, nucleic acids (mRNA, DNA, siRNA), and vaccines without the need to develop new drug delivery formulations from scratch, ultimately speeding up the time it takes for innovative therapeutics to go from the bench to the clinic. The azide-functionalized surface of the LNP can be used to conjugate to DBCO or alkyne-modified biomolecules for active targeting applications including targeting immune cells, cancer cells, or designated tissues throughout the body. This ready to use lipid mix can be used to screen a variety of different targeting moieties to determine what works best for your application or therapeutic. The lipid mix has also been carefully curated specifically for enhanced gene delivery.
advanced drug delivery
Leistungsmerkmale und Vorteile
- A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized lipid nanoparticles
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible lipid nanoparticles
- Optimized to make lipid nanoparticles around 100 nm with low polydispersity
- Optimized lipid blend for DBCO-modified protein or antibody conjugation
- Optimized lipid blend for azide-functionalized lipid nanoparticles for mRNA encapsulation
- For more information, please refer to the protocol under the document section of this page.
Rechtliche Hinweise
NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes
Wang, Fazhan et. al.
Frontiers in Pharmacology, 5:9, 980-980 (2018)
A robust post-insertion method for the preparation of targeted siRNA LNPs
Swart, L et. al.
International Journal of Pharmaceutics, 620, 121741-121741 (2022)
mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting Cells
Lou, Bo
Bioconjugate Chemistry, 30(2), 461-475 (2019)
Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
Wang, Yixiang et. al.
Molecules (Basel), 28(10), 4046-4046 (2023)
Erik Oude Blenke et al.
Journal of controlled release : official journal of the Controlled Release Society, 202, 14-20 (2015-01-28)
The modification of liposomal surfaces is of interest for many different applications and a variety of chemistries are available that makes this possible. A major disadvantage of commonly used coupling chemistries (e.g. maleimide-thiol coupling) is the limited control over the
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