RP1
retinitis pigmentosa 1 (autosomal dominant)
Synonyme:
DCDC4A, ORP1
Spezies:
Human RP1 (6101), Mouse Rp1 (19888), Rat Rp1 (681377), Thale Cress RP1 (840916), Thale Cress RP1 (827869), dog RP1 (403565), cow RP1 (280916), Horse RP1 (100053179), sheep RP1 (101114620), Domestic Rabbit RP1 (100355685) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(6101) Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
- Mouse(19888) retinitis pigmentosa 1 (human)
- Rat(681377) retinitis pigmentosa 1 (human)
- Thale Cress(840916) 60S ribosomal protein L3-1
- Thale Cress(827869) pyruvate, phosphate dikinase regulatory protein 1
- dog(403565) retinitis pigmentosa 1 (autosomal dominant)
- cow(280916) retinitis pigmentosa 1 (autosomal dominant)
- Horse(100053179) retinitis pigmentosa 1 (autosomal dominant)
- sheep(101114620) retinitis pigmentosa 1 (autosomal dominant)
- Domestic Rabbit(100355685) retinitis pigmentosa 1 (autosomal dominant)
- domestic guinea pig(100715117) retinitis pigmentosa 1 (autosomal dominant)
- naked mole-rat(101708003) retinitis pigmentosa 1 (autosomal dominant)
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Antibodies
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Beschreibung
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Anti-RP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-RP1-21O18.1 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot
esiRNA
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