PTEN
phosphatase and tensin homolog
Synonyme:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Spezies:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), naked mole-rat Pten (101714930), domestic guinea pig Pten (100723659), sheep PTEN (101119351), cow PTEN (540786), domestic cat PTEN (101091813), dog PTEN (403832)
UniProtKB-ID:
Gen-ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- naked mole-rat(101714930) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-PTEN Antibody, clone 6B12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse
Anwendung
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-PTEN Antibody, clone 6H2.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse, rat
Anwendung
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN Antibody, clone A2b1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
bovine, canine, feline, human, monkey, mouse, porcine, rat
Anwendung
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN antibody, Rabbit monoclonal, clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody,
Speziesreaktivität
dog, frog, human, mouse
Anwendung
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
western blot