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NR1H4

nuclear receptor subfamily 1, group H, member 4

Synonyme:
BAR, FXR, HRR-1, HRR1, RIP14
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(9971) Summary: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(20186) nuclear receptor subfamily 1, group H, member 4
  • Rat(60351) nuclear receptor subfamily 1, group H, member 4
  • domestic cat(101096997) nuclear receptor subfamily 1, group H, member 4
  • naked mole-rat(101714263) nuclear receptor subfamily 1, group H, member 4
  • cow(540528) nuclear receptor subfamily 1, group H, member 4
  • domestic guinea pig(100734377) nuclear receptor subfamily 1, group H, member 4
  • Zebrafish(436847) nuclear receptor subfamily 1, group H, member 4
  • Horse(100052821) nuclear receptor subfamily 1, group H, member 4
  • chicken(373902) nuclear receptor subfamily 1, group H, member 4
  • dog(612928) nuclear receptor subfamily 1, group H, member 4
  • sheep(101105401) nuclear receptor subfamily 1, group H, member 4
  • Domestic Rabbit(100009485) nuclear receptor subfamily 1, group H, member 4

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
Ursodesoxycholsäure, ≥99%,
Spezies
human
Ursodiol, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Chenodesoxycholsäure, British Pharmacopoeia (BP) Reference Standard,
Spezies
human
Ursodiol, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human
Chenodesoxycholsäure, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-NR1H4 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
bovine, dog, guinea pig, horse, human, mouse, rat
Anwendung
immunohistochemistry
western blot
Monoclonal Anti-NR1H4 antibody produced in mouse, clone 1G11, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence

western blot
Monoclonal Anti-NR1H4, (C-terminal) antibody produced in mouse, clone 1B10, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunofluorescence

western blot
Anti-Farnesoid X Receptor/HRR1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
canine, human
Anwendung
ELISA
western blot

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting mouse Nr1h4,
Spezies
mouse
MISSION® esiRNA, targeting human NR1H4,
Spezies
human