IDE
insulin-degrading enzyme
Synonyme:
INSULYSIN
Spezies:
Human IDE (3416), Mouse Ide (15925), Rat Ide (25700), fruit fly Ide (40248), Zebrafish ide (561390), dog IDE (477768), chicken IDE (423814), sheep IDE (101104194), cow IDE (523752), Horse IDE (100071303) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(3416) Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
- Mouse(15925) insulin degrading enzyme
- Rat(25700) insulin degrading enzyme
- fruit fly(40248) Insulin degrading metalloproteinase
- Zebrafish(561390) insulin-degrading enzyme
- dog(477768) insulin-degrading enzyme
- chicken(423814) insulin-degrading enzyme
- sheep(101104194) insulin-degrading enzyme
- cow(523752) insulin-degrading enzyme
- Horse(100071303) insulin-degrading enzyme
- domestic cat(101093646) insulin-degrading enzyme
- naked mole-rat(101706921) insulin-degrading enzyme
- domestic guinea pig(100719651) insulin-degrading enzyme
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Insulin-degrading enzyme (IDE) antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
western blot
Anti-IDE Antibody, clone 1J8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human, mouse, rat
Anwendung
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-IDE, N-Terminal (97-273) Rabbit pAb, liquid, Calbiochem®,
Speziesreaktivität
hamster, human, mouse, rat
Anwendung
Anti-IDE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
western blot
Anti-IDE antibody produced in rabbit, ,
Speziesreaktivität
human, mouse
Anwendung
immunofluorescence
western blot
western blot