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HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Synonyme:
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(3091) Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
  • Mouse(15251) hypoxia inducible factor 1, alpha subunit
  • Rat(29560) hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • dog(480348) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • domestic guinea pig(100713113) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • naked mole-rat(101715845) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • Domestic Rabbit(100009579) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • sheep(443519) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • cow(281814) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • domestic cat(101083686) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • chicken(374177) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

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ELISA

Produktnummer
Beschreibung
Spezies
Human HIF-1 alpha ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-HIF1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-Hypoxia Inducible Factor 1 α Antibody, clone H1α67, clone H1alpha67, Chemicon®, from mouse,
Speziesreaktivität
ferret, human, mouse, rat
Anwendung
electrophoretic mobility shift assay
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-HIF1A antibody produced in rabbit, ,
Speziesreaktivität
bovine, human, mouse, rat
Anwendung
ChIP
immunocytochemistry

immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-HIF-1 α antibody produced in mouse, clone ESEE122, 1 mg/mL, purified immunoglobulin,
Speziesreaktivität
bovine, human, mouse, rat
Anwendung
ELISA
immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-HIF-1 alpha antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM242, purified immunoglobulin,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot

Cell Lines

Produktnummer
Beschreibung
Spezies
A549 Cells HIF1A -/-/-, ,
Spezies
human
SW48 Cells HIF1A -/-/-, ,
Spezies
human
DLD1 Cells HIF1A -/-, ,
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
HIF-1 α, C-terminal activation domain (776-826 human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Spezies
human
HIF-1 α N-terminal activation domain (530-698) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human HIF1A,
Spezies
human
MISSION® esiRNA, targeting mouse Hif1a,
Spezies
mouse