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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyme:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
D-Serin, ≥98% (TLC),
Spezies
human
Spermin -tetrahydrochlorid, powder or crystals,
Spezies
human
Taurin, ≥99%,
Spezies
human, rat
D-Cycloserin, synthetic,
Spezies
human
Dextromethorphan -hydrobromid Monohydrat, ≥99% (TLC),
Spezies
human

Small Molecule - Allosteric Modulator

Produktnummer
Beschreibung
Spezies
Ketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
(±)-Ketamin -hydrochlorid, solid,
Spezies
human
S-(+)-Ketamine hydrochloride, ,
Spezies
human
Ketamin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard,
Spezies
human
Acamprosatcalcium, ≥98% (HPLC), powder,
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
CP-101,606, ≥98% (HPLC),
Spezies
human
MDL 105,519, ≥98% (HPLC), solid,
Spezies
rat, human
Dextrorphan tartrate, powder,
Spezies
human
Ifenprodil (+)-tartrate salt, ,
Spezies
human
Arcaine sulfate salt, ,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-Glun1-Nr1 antibody produced in mouse, clone S308-48, purified immunoglobulin,
Speziesreaktivität
human, mouse, rat
Anwendung
immunocytochemistry
immunohistochemistry

western blot
Anti-NMDA Receptor 1/GRIN1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Speziesreaktivität
human, mouse
Anwendung
ELISA
immunofluorescence
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Spezies
human
Agmatin -sulfat (Salz), ≥97%, powder,
Spezies
human
Orphenadrin -hydrochlorid, ≥98.0% (AT),
Spezies
human
Orphenadrin für die Peakidentifizierung, European Pharmacopoeia (EP) Reference Standard,
Spezies
human
Orphenadrin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
Taurin, ≥99%,
Spezies
human, rat
Pentamidin Isethionatsalz, powder,
Spezies
human
Orphenadrin -hydrochlorid, ≥98.0% (AT),
Spezies
human
Orphenadrin für die Peakidentifizierung, European Pharmacopoeia (EP) Reference Standard,
Spezies
human
Orphenadrin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human GRIN1,
Spezies
human
MISSION® esiRNA, targeting mouse Grin1,
Spezies
mouse