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CYP1A2

cytochrome P450, family 1, subfamily A, polypeptide 2

Synonyme:
CP12, P3-450, P450(PA)
Spezies:
Human CYP1A2 (1544), Mouse Cyp1a2 (13077), Rat Cyp1a2 (24297), domestic guinea pig Cyp1a2 (100135513), domestic cat CYP1A2 (554345), chicken CYP1A2 (414856), cow CYP1A2 (503552), dog CYP1A2 (494010)
UniProtKB-ID:
P05177, Q16754, Q6NWU5, Q9BXX7, Q9UK49
Gen-ID:
  • Human(1544) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
  • Mouse(13077) cytochrome P450, family 1, subfamily a, polypeptide 2
  • Rat(24297) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic guinea pig(100135513) cytochrome P450, family 1, subfamily a, polypeptide 2
  • domestic cat(554345) cytochrome P450 1A2
  • chicken(414856) cytochrome P450, family 1, subfamily A, polypeptide 2
  • cow(503552) cytochrome P450, family 1, subfamily A, polypeptide 2
  • dog(494010) cytochrome P450, family 1, subfamily A, polypeptide 2

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
AB1248
Anti-Cytochrome P450 Enzyme CYP1A2 Antibody, serum, Chemicon®,
Speziesreaktivität
human
Anwendung
immunohistochemistry
western blot
SAB1401102
Anti-CYP1A2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot
SAB1408927
Anti-CYP1A2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
C0378
Chloramphenicol, ≥98% (HPLC),
Spezies
human
183164
(R)-(+)-Limone, 97%,
Spezies
human
A88107
p-Anisaldehyd, 98%,
Spezies
human
185515
Pyren, 98%,
Spezies
human
147141
Naphthalin, 99%,
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
MTOXCE1A2
CypExpress™ 1A2 Cytochrome P450 human, ,
Spezies
human
C5614
Cytochrome P450 human, 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EHU001461
MISSION® esiRNA, targeting human CYP1A2,
Spezies
human