Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, ≥99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

GF57762399

Platinum, foil, not light tested, 50x50mm, thickness 0.005mm, as rolled, 99.95%

GF58265488

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%

GF30259357

Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.95%

GF43288487

Platinum, wire reel, 0.05m, diameter 1.0mm, annealed, may be used as one component of a thermocouple, 99.99%

GF04529538

Platinum, foil, 50x50mm, thickness 0.125mm, as rolled, 99.99+%

GF19165552

Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%

GF15087203

Platinum, foil, 0.1m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%

GF43907799

Platinum, foil, 15mm disks, thickness 0.005mm, as rolled, 99.95%

GF13420257

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 5mm, as rolled, 99.95%

GF26290313

Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

GF73706058

Platinum, foil, 10mm disks, thickness 0.0125mm, as rolled, 99.95%

GF19578831

Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%

GF06440048

Platinum, foil, 4mm disks, thickness 0.05mm, as rolled, 99.95%

GF83172269

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF60594442

Platinum, foil, 0.5m coil, thickness 0.025mm, coil width 8mm, as rolled, 99.95%

GF96551354

Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%

GF29981199

Platinum, wire reel, 0.1m, diameter 0.002mm, wollaston, 99.9%