- Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes.
Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes.
Experientia (1983-05-15)
E E Guibert, L S Morisoli, J A Monti, E A Rodriguez Garay
PMID6406259
ABSTRACT
The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may induce PNP glucuronidation in the hepatocyte.