- On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing.
On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (2013-02-01)
Gusphyl A Justin, Siqiang Zhu, Theodore R Nicholson, Jeffrey Maskrod, Joseph Mbugua, Mark Chase, June-ho Jung, Ramil Marcelo L Mercado
PMID23366114
ABSTRACT
An electronically-controlled drug delivery system (eDDS) for the on-demand release of anti-inflammatory, anti-microbial and analgesic agents to aid in wound healing is currently under development. The loading of several drugs into conductive polymer films and their subsequent on-demand, controlled release upon application of an electrical potential to the polymer film has been demonstrated. The loading and release (active and passive) of Ibuprofen sodium salt - a negatively charged analgesic and anti-inflammatory agent - from polypyrrole films is described. Major challenges identified include precise control over drug loading and passive release from the conducting polymers in the absence of an applied potential.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Polypyrrole, doped, conductivity 0.5-1.5 S/cm (pressed pellet, typical), extent of labeling: ~5 wt. % loading, coated on titanium dioxide
Sigma-Aldrich
Polypyrrole, doped, conductivity 30 S/cm (bulk), extent of labeling: 20 wt. % loading, composite with carbon black