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  • Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum.

Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum.

Phytomedicine : international journal of phytotherapy and phytopharmacology (2012-10-23)
Janki Prasad, Atul Shrivastava, A K Khanna, G Bhatia, S K Awasthi, T Narender
ABSTRACT

In continuation of our drug discovery program on Indian medicinal plants, we isolated bioactive compounds (1-5) from the leaves of Calophyllum inophyllum and evaluated their antidyslipidemic activity in triton induced hyperlipidemia model. The calophyllic acid (1A) and isocalophyllic acid (1B) mixture, canophyllic acid (4) and amentoflavone (5) showed dose dependent lipid lowering activity in in vivo experiments. The compounds 1A+1B mixture and 3 also showed good in vitro antioxidant activity.

MATERIALS
Product Number
Brand
Product Description

Supelco
Amentoflavone, analytical standard
Sigma-Aldrich
Amentoflavone, ≥98.0% (HPLC)