- Phosphorylation of G3BP1-S149 does not influence stress granule assembly.
Phosphorylation of G3BP1-S149 does not influence stress granule assembly.
The Journal of cell biology (2019-06-07)
Marc D Panas, Nancy Kedersha, Tim Schulte, Rui M Branca, Pavel Ivanov, Paul Anderson
PMID31171631
ABSTRACT
Tourrière et al. (2013. J. Cell Biol. https://doi.org/10.1083/jcb.200212128) reported that G3BP1-S149 dephosphorylation promotes stress granule formation. We show that constructs used to establish this conclusion contain additional mutations causing these phenotypes, and that S149 phosphorylation status does not change upon stress.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Anti-phospho-G3BP (pSer149) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution